TL;DR
MiR-642b-3p is upregulated in sICH and mediates thrombin-induced endothelial cell injury, at least in part, by targeting CCNA2.
The findings support that restoration of miR-642b-3p alleviates post-ICH cerebral edema and neurological deficits via targeted inhibition of SERPINE1-mediated inflammation, involving suppression of NLRP3 inflammasome and promotion of M2 polarization.
BACKGROUND Sevoflurane (Sevo) is widely applied in clinical anesthesia practice, and exposure to this agent has been linked to cognitive impairment. PURPOSE This study aimed to explore how microRNA-519a-3p (miR-519a-3p) contributes to Sevo-induced cognitive impairment and the molecular mechanisms involved. METHODS...
Background Sepsis is frequently complicated by systemic inflammatory injury and cardiac dysfunction, which serve as risk factors of adverse clinical outcomes and increased mortality risk. To clarify the function of miR-130a-3p in sepsis diagnosis and its regulatory role in sepsis-induced inflammatory injury and cardiac...
Intracranial aneurysms (IAs) are a significant cause of morbidity and mortality, often leading to subarachnoid hemorrhage and subsequent neurological deficits. The kinase insert domain receptor (KDR) plays a crucial role in vascular cell function during IA. However, the mechanism responsible for KDR’s role in IA remain...
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