Salvianolic acid B suppresses non-small cell lung cancer growth by promoting Nrf2 proteasomal degradation and triggering autophagy-dependent ferroptosis.
Jul 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 0 citations· 32 references
Medicine
TL;DR
It is established that SalB suppresses NSCLC progression by promoting Nrf2 proteasomal degradation, thereby enhancing autophagy-associated ferroptotic vulnerability and pharmacological targeting of the Nrf2-autophagy-ferroptosis regulatory axis.
USP7 suppresses ferroptosis and enhances growth in NSCLC cells by stabilizing SETDB1 protein through deubiquitination, and Mechanistically, USP7 enhanced the stability of SETDB1 protein by its deubiquitination.
Hong-Pei Zhang, Yan-Feng Fang, Xin-Xin Wang et al.· General Physiology and Bioph...· 0 citations
Highlights • 11-oxo-mogroside V suppresses LUAD progression in vitro and in vivo.• It disrupts metabolic homeostasis by reducing ATP, glucose, and LDH.• The compound induces G0/G1 arrest and promotes apoptosis in cancer cells.• It directly targets TGFβ2, HDAC1, and c-Myc to block oncogenic signaling.• Multi-pathway int...
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The findings identify medicarpin as a novel EGFR‑modulating natural compound that induces Fas-mediated apoptosis in liver cancer, independent of p53 status.
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These in vivo experiments further demonstrated that LTN exhibits a significant inhibitory effect on tumor growth in a lung cancer model, indicating that LTN, as a natural compound, exhibits the potential for multi-target action in the treatment of NSCLC.
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Initial evidence is provided that marbofloxacin induces metabolic and molecular rewiring in BC, highlighting its promise as a repositionable therapeutic candidate.
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Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer characterized by poor prognosis and limited therapeutic options, remains a major clinical challenge. Bufalin, a principal bioactive component of Venenum Bufonis, exhibits potent anticancer activity against breast cancer. Nevertheless, th...
Ji-Ying Zhou, An-Xin Wang, M. Jin et al.· The American Journal of Chin...· 0 citations
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