Aug 2026· Cardiovascular Drugs and Therapy· 1 citation· 44 references
Medicine
TL;DR
This review proposes a hypothesis-generating conceptual framework that categorizes SHS into three endophenotypes, including neurogenic arrhythmic (Type I), inflammatory thrombotic (Type II), and metabolic remodeling (Type III), and potential phenotype-specific interventions include beta blockers for neural stabilization, NETs degradation for immunomodulation, and metabolic pathway antagonists.
Renin–angiotensin system inhibitors, sodium–glucose cotransporter-2 inhibitors, finerenone, and glucagon-like peptide-1 receptor agonists improve cardiorenal outcomes and have plausible anti-inflammatory actions, although inflammatory mediation remains unproven.
Aris Tsalouchos, P. Dattolo· Journal of Clinical Medicine· 0 citations
This review systematically delineates the spatiotemporal dynamics and functional duality of TREM2+ macrophages across major cardiovascular conditions, and further evaluates the current evidence and limitations of soluble TREM2 (sTREM2) as a candidate biomarker and critically appraises translational strategies targeting...
Ke Yang, Xue-Fang Ma, Bin-Yan Wang et al.· Journal of Advanced Research· 1 citation
The present review systematically outlines the clinical manifestations, core pathogenic mechanisms and emerging therapeutic strategies for CKD‑associated encephalopathy, and the targeted interventions on the gut‑kidney‑brain axis.
Nanling Zeng, Ling Jiang, Yang Zhang et al.· Molecular Medicine Reports· 0 citations
This review analyzes the adverse impact of HPA axis dysregulation on post-stroke outcomes across disease phases and elucidating these neuroendocrine-immune interactions provides a novel pathophysiological framework for understanding post-stroke multidimensional complications.
Han Gong, Dan Liu, Xiang-Zheng Wang et al.· Frontiers in Human Neuroscie...· 0 citations
The gut microbiota modulates the onset and progression of post-stroke neuroinflammation through multidimensional mechanisms via the “immune-neuro-endocrine” feedback pathway at multiple levels at multiple levels.
Lili Teng, Minmin Wu, Wenjing Song et al.· Journal of Translational Med...· 0 citations
A testable precision medicine paradigm integrating multimodal biomarkers to identify high risk individuals and guide targeted interventions is proposed to improve long term outcomes in this vulnerable population of stroke patients.
