TL;DR
Current understanding of PINK1-Parkin-dependent and independent mitophagy pathways are summarized, highlighting mechanistic distinctions and coordinated regulation, as well as the expanding therapeutic potential of targeting mitophagy in disease.
This review provides a comprehensive overview of the best-characterized PINK1-PRKN/parkin-dependent mitophagy pathway and the expanding repertoire of PRKN-independent mechanisms, including additional ubiquitin-dependent, receptor-mediated, and lipid-mediated pathways.
Ten key PTMs, including lactylation, succinylation, succinylation, SUMOylation, and S-nitrosylation, acting on core regulators such as dynamin-related protein 1(DRP1), optic atrophy 1 (OPA1), Parkin, and mitochondrial Rho GTPase 1 (MIRO1) are summarized to provide a comprehensive resource for understanding mitochondria...
This review critically assess the AMP-activated protein kinase (AMPK)–UNC-51-like kinase 1 (ULK1), sirtuin 3 (SIRT3)–peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), PTEN-induced kinase 1 (PINK1)–Parkin E3 ubiquitin ligase, and hypoxia-inducible factor 1-alpha
It is shown that ER calcium signalling promotes longevity during mitochondrial stress by regulating actin-dependent mitochondrial remodeling, identifying an inter-organelle signaling axis linking ER calcium release and cytoskeletal remodeling to adaptive mitochondrial responses associated with longevity.
It is hypothesized that FCCP-induced mitochondrial depolarization activates the PINK1-Parkin-mediated mitophagy pathway, culminating in the clearance of damaged mitochondria, and these findings demonstrate that FCCP robustly activates the canonical PINK1-Parkin mitophagy pathway in hASM cells.
Although mtISR has been characterized in primary mitochondrial myopathies, secondary mitochondrial dysfunction in neuromuscular disorders suggests that mtISR-related pathways may also be activated in these conditions, and its roles in skeletal muscle pathology are discussed.
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
