Joint contributions of metabolic dysfunction and biological aging to cardiometabolic multimorbidity and disease progression: a prospective cohort study

Cumulative lipid–inflammatory indices and the risk of cardiometabolic multimorbidity: a prospective cohort study

Background Cardiometabolic multimorbidity (CMM) has become a major global public health challenge. Although dyslipidemia and chronic low-grade inflammation are known to contribute to cardiometabolic diseases, their long-term cumulative combined effects on the risk of CMM remain poorly understood. This study aimed to ev...

Impact of lipid accumulation product on cardiometabolic multimorbidity and the mediating effect of leukocytes: evidence from a prospective cohort study among middle-aged and elderly chinese adults

Cardiometabolic multimorbidity (CMM) is a growing public-health burden in ageing populations, yet conventional adiposity measures such as body mass index and waist circumference do not adequately capture the visceral fat and lipid-metabolic disturbances that underlie it. We investigated the association between the lipi...

Estimated glucose disposal rate shows the broadest associations with cardiometabolic multimorbidity progression in early cardiovascular–kidney–metabolic stages: a longitudinal cohort study

Background Early risk stratification may help prevent cardiometabolic multimorbidity (CMM) among adults at cardiovascular–kidney–metabolic (CKM) stages 0–3. We compared the estimated glucose disposal rate (eGDR), triglyceride–glucose (TyG) index, and atherogenic index of plasma (AIP) for incident CMM, disease transitio...

Estimated cardiorespiratory fitness and incident cardiometabolic multimorbidity: findings from three nationally representative cohorts

Associations of biological aging and biological age acceleration with mortality in patients with cardiorenal syndrome: A prospective cohort study.

KDM-BA, KDM-BA, PhenoAge, KDM-BAA, and PhenoAgeAccel are significantly associated with all-cause mortality among the CRS population, with a non-linear relationship observed in cerebrovascular disease.

Combined associations of triglyceride-glucose index and biochemical sarcopenia index with cardiometabolic multimorbidity in middle-aged and older Chinese adults.

The triglyceride-glucose index is a robust and independent predictor of incident cardiometabolic multimorbidity and shows a very small incremental improvement over the TyG index alone, though the clinical significance is uncertain and requires external validation.