Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain

Abstract

Developmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and dementia risk, we assessed the impact of perinatal Pb exposure on dementia‐related outcomes in the murine brain.