Heat shock protein family D member 1 (HSPD1) modulates ribosome-related pathways and protein synthesis in lung adenocarcinoma

GPX3 suppresses lung adenocarcinoma progression through HSPB1 ubiquitination and Hippo pathway activation.

A robust prognostic model based on manganese metabolism-related genes is established and the critical regulatory role of the GPX3/HSPB1/yes-associated protein (YAP) axis in LUAD progression is uncovered, underscoring the therapeutic potential of targeting GPX3.

HSP27 Provides Stress-Adaptive Proteostasis Buffering in Glioblastoma and Is Therapeutically Vulnerable

Glioblastoma, isocitrate dehydrogenase (IDH)-wildtype (GBM), remains one of the most aggressive primary brain tumors, and its proteostasis machinery represents a potential therapeutic target. Here we identify HSP27 as a key regulator-associated proteostasis in glioblastoma, IDH-wildtype, where it is linked to protein s...

CAPRIN-1: molecular functions, oncogenic impact and emerging roles in the immune system

Cell cycle-associated protein 1 (CAPRIN-1) is an RNA-binding protein involved in multiple cellular processes, including cell proliferation, differentiation and stress responses. It exerts its functions by regulating the stability and translation of specific messenger RNAs as well as by promoting stress granule format...

Targeting FEN1 disrupts EIF4A3-mediated MUC1-C autoregulation: a novel strategy to suppress lung adenocarcinoma progression

The FEN1/EIF4A3/MUC1-C axis is established as a novel mechanism driving LUAD progression by concurrently regulating intrinsic malignancy and extrinsic immune evasion, presenting FEN1 targeting as a promising dual-hit therapeutic strategy.

RBM protein family: Focusing on the occurrence, progression and treatment of cancer

Levistilide A promotes ferroptosis through the RNF40-HSP90α axis and inhibit colorectal cancer lung metastasis

It is demonstrated that heat shock protein 90α (HSP90α) is markedly upregulated in CRC and promotes lung metastasis by suppressing ferroptosis and combined treatment with LeA and the ferroptosis inducer RSL3 further alleviates lung metastatic burden in vivo.