Naringenin protects against renal ischemia-reperfusion injury following unilateral nephrectomy via modulation of oxidative stress and kisspeptin expression.
Jul 2026· International Urology and Nephrology· 0 citations· 43 references
Medicine
TL;DR
A novel finding is the restoration of kisspeptin expression by NRG, particularly when administered at reperfusion, suggesting timing-dependent therapeutic potential.
Renal ischemia–reperfusion (I/R) injury is a leading cause of acute kidney injury and is driven by oxidative stress, sterile inflammation, and regulated cell death. Vortioxetine (VOR), a multimodal antidepressant, carries anti-inflammatory and antioxidant activity beyond its neuropsychiatric actions, but has not been t...
Resul Çiçek, Ibrahim Topcu, Bulut Dural et al.· International Journal of Mol...· 0 citations
Background: Renal ischemia–reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). It is associated with reduced blood flow as encountered in vascular surgery, including aortic aneurysm repair and kidney transplantation. In this study, we investigated whether pre- and/or post-administration of sodiu...
George J. Dugbartey, Liam McFarlane, T. Shamma et al.· Antioxidants· 0 citations
BACKGROUND
Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) with significant clinical impact. Gentiopicroside (GPS), a natural secoiridoid glycoside isolated from traditional medicinal plants, has been reported to exert anti-inflammatory and cytoprotective activities, yet its potent...
Lan Luo, Jia Liu, Na Zhang et al.· European Journal of Pharmaco...· 0 citations
The application of tourniquets during limb surgery can lead to ischemia-reperfusion (IR) injury, a pathological process characterized by excessive oxidative stress, increased inflammatory signaling, and progressive muscle fiber damage. Hesperidin, a bioactive flavonoid derived from citrus fruits, is known for its antio...
A. J. Albarakati· Journal of Visualized Experi...· 0 citations
Introduction: Renal ischemia-reperfusion (IR) injury is a major cause of acute kidney injury and is strongly associated with oxidative stress, inflammation, and apoptosis. Melatonin and Nigella sativa possess well-documented antioxidant and anti-inflammatory properties that may provide renoprotective effects against IR...
Y. Hussein, Salim Kadhim, Lafta Fayez Kadhim et al.· Eurasian Journal of Medicine...· 0 citations
This study aimed to evaluate the renoprotective benefits of remote ischemic postconditioning (RIPostC) and alpha-lipoic acid)ALA( against acute kidney injury (AKI) secondary to ischemia-reperfusion, focusing on the role of the TLR4/MyD88/NF-κB signaling cascade and the involvement of Nrf2 and HO-1. Individual and combi...
Murtadha Ghafil Jasim Hamdan, F. Gholampour, Zeinab Karimi et al.· Tissue & Cell· 0 citations
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