It is proposed that the glycolytic pathway may function as a signaling hub that integrates metabolic status and regulation of the fate of bone cells, providing a novel perspective for understanding bone metabolic diseases.
Bone homeostasis is a dynamic process governed by the balanced activity of osteoblasts and osteoclasts, tightly regulated through complex signaling networks. Emerging evidence highlights sphingolipid metabolism as a critical modulator of skeletal integrity, influencing bone remodeling in both health and disease. Each i...
Jett B. Murray, Peter Kim, P. Lehmann et al.· Lipidology· 0 citations
This review summarizes the current evidence that H₂S participates in skeletal remodeling through coordinated regulation of osteoblast-lineage cells, osteoclasts, macrophage-mediated immune responses, and metabolic stress adaptation.
This review integrates glutamatergic signaling with the intracellular glutamine (Gln)-Glu-α-ketoglutarate (α-KG)-glutathione (GSH) pathway and examines how Glu availability is translated into cell-specific responses.
Yu-Xin Liu, Li-Yuan Chen, He Zhang et al.· Frontiers in Dental Medicine· 0 citations
It is proposed that ERK5 may shift the threshold between adaptive survival and ferroptotic injury in a cell-, stress-, and disease-stage-dependent manner, providing a testable framework for skeletal degeneration and regeneration.
Jiang-Ying Zhang, Xi-Ping Dou, Hao-Chuan You et al.· Biomolecules· 0 citations
Osteoporosis has long been understood, and treated, as an imbalance between osteoblastic bone formation and osteoclastic resorption. Yet many patients continue to lose bone, pointing to upstream regulators of the remodeling unit that remain poorly defined. Macrophages are developmentally continuous with osteoclasts and...
Lian Weng, Qian-Li Yuan, T. Mo et al.· Frontiers in Immunology· 0 citations
The aging population has led to a significant increase in the prevalence of osteoporosis, making it an important public health issue. Emerging evidence suggests that osteoporosis is related to glucose metabolic reprogramming (GMR). Exercise is an effective non-pharmacological intervention method, and regulating GMR may...
Chu Li, Yu-Ting He, Kai-Hong Weng et al.· Sports Medicine - Open· 0 citations
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