Oct 2026· Clinical medicine (London)· Vol 26, pp.
100656
· 1 citation· 24 references
Medicine
TL;DR
It is suggested that cancer-related ischemic stroke is a unique subtype of stroke, including a newly proposed schematic to define this subgroup of patients.
Abstract
Cancer and acute ischemic stroke are two leading causes of mortality worldwide. The association between these two diseases is being increasingly recognized, and with improvements in cancer mortality, the co-prevalence is increasing. Evidence suggested that cancer-related ischemic stroke is a unique subtype of stroke, including a newly proposed schematic to define this subgroup of patients. Cancer-related ischemic stroke encompasses a heterogeneous group of mechanisms that requires individualized diagnostic evaluation and multidisciplinary collaboration. In this narrative review, we describe the pathophysiology, workup, and management considerations in patients with cancer and ischemic stroke.
The molecular mechanisms of cuproptosis and its potential involvement in cerebral ischemia are summarized, and the therapeutic potential of cuproptosis-targeting agents for improving neurological outcomes after stroke is discussed.
Xin-Yu Han, Wen-Jing Zhang, Huan-Huan An et al.· Molecules· 0 citations
CAC-related stroke is a distinct and underrecognized entity characterized by specific biological and radiological features and poor outcomes, and earlier recognition and optimized antithrombotic strategies may improve prognosis.
Carlota Jauregui Larrañaga, Emilio Gómez Arteta, J. Marta Enguita et al.· Journal of Neurology· 0 citations
Dual antiplatelet therapy (DAPT)—a combination of two antiplatelet agents—is sometimes prescribed for high-risk patients to provide greater protection against recurrent strokes, but balancing the benefits of stroke prevention with the risk of bleeding complications remains a clinical challenge.
Deepak Kumar Punna, Sumana Chatla, A. K. Sharma et al.· 0 citations
Cancer-associated thrombotic complications are common in oncological patients and often proceed with significant complications, leading to increased morbidity and mortality. They are the result of a complex interaction between tumor-specific factors, individual patient characteristics, and the type of oncological treatme...
B. Krastev, N. Spasova, D. Somleva et al.· Bulgarian Cardiology· 0 citations
This study aimed to provide population‐based estimates of ischemic stroke risk after cancer diagnosis across multiple cancer sites and demographic subgroups.
C. Libruder, D. Tanne, B. Silverman et al.· Cancer· 1 citation
Stroke in young adults represents a distinct clinical entity with diverse and often unconventional etiologies. Unlike older populations where atherosclerosis predominates, young stroke frequently arises from cardioembolic, genetic, autoimmune, or vascular structural causes. Early identification of these conditions is c...
Kalpana P, Anisha Ashra, Alex J et al.· Adolescência e Saúde· 0 citations
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