Exposure to heavy metals has been associated with changes in gene expression in urothelial bladder cancer (UBC), suggesting that environmental carcinogens may play a vital role in development and progression of bladder tumour.
Abstract
Chronic exposure to heavy metals and occupational hazards is positively associated with carcinogenesis, although the underlying mechanisms remain poorly understood. The present study evaluated the association between heavy metal exposure and epigenetic alterations/modifications in blood, urine, and tissue samples from patients with UBC and control. ICP-MS measured heavy metal concentrations in blood, urine, and tissue samples, whereas ELISA assessed epigenetic modifications. The study categorically revealed that patients with UBC exhibited significantly elevated blood lead levels and urinary cadmium, arsenic, and chromium compared with controls. Exposure to heavy metals has been associated with changes in gene expression in urothelial bladder cancer (UBC), suggesting that environmental carcinogens may play a vital role in development and progression of bladder tumour.
Environmental exposure to heavy metals has been associated with cancer. Nonetheless, the effects of exposure to combined heavy metals on cancer mortality of urinary and gastrointestinal systems have not been examined. This study assessed the long-term association between environmental exposure to multiple heavy metals...
Marcel Jhonnata Ferreira Carvalho, Gustavo Fonseca, A. V. Borges et al.· Ciência & Saúde Coletiva· 0 citations
Aromatic amines are environmental and occupational pollutants found in industrial chemicals, tobacco smoke, hair dyes, and azo-dye-containing textiles. Epidemiological studies confirm that occupational settings and tobacco smoking are the primary sources of exposure, with inhalation and dermal absorption being the majo...
Shu-Xin Li, Yue-Qiu Zhang, Tie Mao et al.· Frontiers in Cell and Develo...· 0 citations
Introduction The extensive use of TiO2 for several applications poses the problem of its safety. Notably, TiO2 has been classified as type Group 2 B carcinogen by IARC in 2010. It is widely known that DNA methylation is influenced by the exposure to environmental triggers, including occupational risk factors. The aim o...
Eleonora Loi, L. Moi, F. Floris et al.· Frontiers in Toxicology· 0 citations
Colorectal cancer (CRC) is a major contributor to global cancer morbidity and mortality, with heavy metal exposure increasingly implicated in its development. Several studies report differences in blood heavy metal profiles between CRC patients and healthy individuals, yet clinical relevance to surgical and chemotherap...
M. Syafiie, T. Y. Aditama, Fairuz Quzwain et al.· PharmaCine : Journal of Phar...· 0 citations
Occupational cadmium exposure was associated with concurrent changes in endocrine and endothelial biomarkers among male workers, and combined assessment of endocrine and endothelial biomarkers may be useful for occupational monitoring of workers with chronic cadmium exposure.
Deniz Ozkan Vardar, L. Tutkun, S. Iritaş et al.· BMC Endocrine Disorders· 0 citations
Findings demonstrate that subchronic Cd exposure promotes RCC cell proliferation in vitro and highlight Cd as a relevant environmental modifier of RCC progression and underscore the need for further investigation into its clinical implications for metastasis and disease management via in vivo mouse models currently in...
P. Mallon· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
