MBene-Empowered Multifunctional Sprayable Hydrogel for Burn Wound Treatment.

Abstract

Burn wounds are challenging to heal due to irregular tissue architecture, high bacterial susceptibility, excessive oxidative stress, and prolonged inflammation. Here, we report a multifunctional sprayable hydrogel (PM) by integrating MoB (MBene) nanosheets into a thermoresponsive Pluronic F127 matrix for comprehensive burn wound therapy. Benefiting from electron-deficient boron sites and multivalent Mo states, MoB exhibits robust SOD- and CAT-mimetic activities, enabling efficient ROS scavenging, restoration of mitochondrial homeostasis, and macrophage polarization toward an anti-inflammatory M2 phenotype. Meanwhile, MoB shows high photothermal conversion efficiency, endowing the hydrogel with potent photothermal antibacterial activity, achieving >90% bacterial inhibition. In vivo studies demonstrate that PM hydrogel combined with light irradiation effectively remodels the wound microenvironment and markedly accelerates healing of infected burn wounds, reaching a 94% healing rate by day 14. Transcriptomic analyses further reveal that PM promotes tissue repair by modulating immune responses, enhancing cell migration and differentiation, and activating wound-regeneration-related pathways. Overall, this MoB-empowered sprayable hydrogel represents a promising, translatable platform integrating antioxidative, immunomodulatory, and antibacterial functions for effective management of infected burn wounds.