Combined Vitamin D and Resveratrol Treatment Attenuates Motor Deficits and Neurodegeneration in a 6‐OHDA Mouse Model of Parkinson's Disease in Male Mice: A Focus on Sirt1 and Lingo‐1 Pathways in the Ventral Tegmental Area
Aug 2026· Brain and Behavior· Vol 16· 0 citations· 47 references
Medicine
TL;DR
Given the neuroprotective properties of Vitamin D3 and resveratrol, this study examined whether their combined administration could modulate Sirt1 and Lingo‐1 expression and attenuate neurodegeneration in a 6‐hydroxydopamine (6‐OHDA) model of PD.
Abstract
Parkinson's disease (PD) is characterized by progressive dopaminergic neurodegeneration, leading to severe motor impairments. Lingo‐1 negatively regulates neuronal survival, while Sirtuin‐1 (Sirt1) supports mitochondrial function and oxidative stress resistance. Given the neuroprotective properties of Vitamin D3 (VitD3) and resveratrol, this study examined whether their combined administration could modulate Sirt1 and Lingo‐1 expression and attenuate neurodegeneration in a 6‐hydroxydopamine (6‐OHDA) model of PD.
Clear pharmacological evidence is provided that the neuroprotective effect of regular treadmill exercise against chronic PD strictly depends on the Nrf2-ARE pathway, indicating that Nrf2 is a key mechanistic node linking exercise and neuroprotection.
Shu-Wei Zhang, Dong Yang, Chang-Fa Tang et al.· International Journal of Mol...· 0 citations
Key research gaps identified include the absence of systematic dose-response studies using zinc in the OVX+D-galactose model, limited exploration of therapeutic zinc administration following AD-like pathology establishment, and the uncharacterized role of the Nrf2 pathway under conditions of combined estrogen deficienc...
Novi Dewi Tanjung· Jurnal Biomedika dan Kesehat...· 0 citations
Preclinical evidence is provided on the neuroprotective potential of Ayurvedic polyherbal formulation, Neurogrit Gold, positioning it as a promising natural candidate for further investigation in advanced animal models of Parkinson's disease.
A. Balkrishna, Simran Kauts, Sandeep Kumar et al.· Brain Research· 0 citations
The natural flavonoid Astragalin concurrently addresses three core pathological processes in PD, namely dopaminergic neuron degeneration, α-synucleinopathy, and neuroinflammation, through coordinated modulation of interconnected molecular pathways.
Jun Wang, Jie-Yu He, Qin Huang et al.· Free Radical Biology & Medic...· 0 citations
This model indicates the therapeutic potential of oral NaB and provides a translational framework for investigating the mechanisms of NaB therapy in PD and associated neurological disorders and alleviated motor and non-motor deficits in rats with 6-OHDA-induced PD.
Shun-Tai Yang, Yang-Ching Chen, Tzu-Jen Kao et al.· BMC Neuroscience· 0 citations
Acute liver failure (ALF) is a life-threatening condition often leading to hepatic encephalopathy (HE), a neuropsychiatric disorder characterized by cognitive deficits and motor dysfunction due to elevated ammonia levels and neuroinflammation. This study investigates the therapeutic potential of resveratrol (RSV), a SI...
