ApoE3-Decorated Porous MnO₂ Nanoplatform for ROS-Responsive Delivery of Defensamide and Mitigating Neuroinflammation to Alzheimer's Brain

Abstract

Neuroinflammation is a key feature of Alzheimer's disease (AD) and plays a significant role in its progression. In AD brains, the downregulation of a special enzyme, SphK1 impairs lipid homeostasis,...