Learning with interacting dendrites improves neuronal familiarity detection

Plasticity degeneracy underlies flexible formation and reconfiguration of spatial representations in hippocampal granule cells

Dendritic hotspots support switching between competing rules without expanding the cortical engram

Adaptive behavior requires updating responses when contingencies change while preserving prior associations and the capacity to learn a new. How this trade-off is resolved remains unknown. Here, we combined in vivo imaging of apical tuft spines in the secondary motor cortex (M2) with biologically constrained network mo...

Dendritic structure enables powerful plasticity

It is argued that the ability of single neurons to simultaneously encode multiple pieces of information gives synapses local access to more than just the classical Hebbian pre- and postsynaptic terms, and with much greater specificity and reaction speed than permitted by other globally modulated factors.

Tuft Dendrite Spikes Are Accompanied by Selective Input From Distinct Functional Networks

The results suggest that tuft spikes may be particularly driven by inputs from neurons that are both embedded in sparse subnetworks and synchronized through coupling to larger-scale functional networks.

Plateau-gated one-shot plasticity supports continual recognition memory

Instructive signals drive learning through behavioral timescale synaptic plasticity in the hippocampus and beyond

Observations support a view of BTSP as a multi-factor plasticity rule that links synaptic, circuit, and systems-level processes, providing a biologically grounded framework for understanding how the brain rapidly incorporates new information.