Limited G-dependent residual infectivity of G gene–deleted vesicular stomatitis virus

Abstract

Highlights • Residual VSV-G determines infectivity of VSV-ΔG vector particles.• Anti-VSV-G neutralization abolishes residual VSV-ΔG infection.• VSV-ΔG particles show limited passage-dependent infectivity.• G carryover control is critical for VSV-ΔG vector biosafety.