Aug 2026· Lupus· Vol 35, pp. 1440 - 1443· 0 citations· 7 references
Medicine
TL;DR
A case of a juvenile lupus who developed disseminated Nocardia pseudobrasilienisis infection in form of necrotizing pneumonia, subcutaneous nodules and central nervous system (CNS) lesion in the right parietal lobe is reported.
Abstract
Nocardiosis is an uncommon infection that presents as a chronic, debilitating illness with radiographic manifestations simulating lung cancer or tuberculosis. Immunocompromised hosts may develop a fulminant disease resembling acute bacterial pneumonia or disseminated disease. We report a case of a juvenile lupus who developed disseminated Nocardia pseudobrasilienisis infection in form of necrotizing pneumonia, subcutaneous nodules and central nervous system (CNS) lesion in the right parietal lobe, following inadvertent hiking of steroids after a minor organ flare. This case was successfully treated with intravenous meropenem, amikacin, and oral cotrimoxazole therapy for 6 weeks which lead to resolution of pneumonia, and partial resolution of of the cutaneous and CNS lesion. As the patient was immunosuppressed, and had disseminated nocardiosis, we planned to put her on oral cotrimoxazole for the next 1 year.
The case of a 48-year-old patient recently diagnosed with HIV and a CD4 lymphocyte count of less than 50 cells/ uL, who consulted for prolonged fever without apparent focus, highlights the importance of considering nocardiosis in the differential diagnosis of prolonged fever with multiple deep lesions in immunocompromi...
María Trinidad Pennini Guelfi, Camilo Martínez, Ana De Lajonquiere et al.· Medicina· 0 citations
A 78-year-old man who came to an out-patient clinic for progressive ulcerative cutaneous lesions for 6 months with concurrent pulmonary symptoms and osteomyelitis is reported, negative for infectious organisms and therapeutic trial of standard anti-tuberculous regimen failed to improve clinical symptoms.
Natthapong Suthammopasut, Athitaya Luangnara· International Journal of Inf...· 0 citations
A case of septic arthritis caused by N. asiatica is reported in a 72-year-old man with a history of chronic obstructive pulmonary disease and pneumoconiosis, who presented with subacute knee swelling following a recent episode of pneumonia.
Mehmet Yıldız· Revista do Instituto de Medi...· 0 citations
The presence of severe melioidosis in the Peruvian Amazon highlights the presence of Burkholderia pseudomallei and underscores the need to consider this pathogen in patients presenting with severe sepsis in tropical regions with high environmental exposure and metabolic risk factors.
Mario Agramonte-Vilca, Stefany Alvis-Sanchez, Débora Rocío Mananita-Terrones et al.· American Journal of Tropical...· 0 citations
A 77-year-old woman with a medical history of hypertension and diabetes presented with ulcerated purplish-red nodules on the lower extremities that had persisted for 3 months, and subsequent treatment with oral trimethoprim–sulfamethoxazole led to gradual regression of the lesions and scar formation.
Nai-Xuan Lin, Ke-Ke Huang, De-Gang Yang· American Journal of Tropical...· 0 citations
We report a rare case of disseminated cryptococcosis gattii infection with initial central nervous system manifestations in a 28-year old male under regular treatment for systemic lupus erythematosus since 2020. He presented with headache evolving into hearing loss, hypogeusia, amblyopia and mental confusion. This case...
Gabriel Nery da Silva Menezes, Eduardo Ráfaga Gonçalves Calvoso· Tropical doctor· 0 citations
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