Levels of Lipoprotein-associated Phospholipase A2 (LP-PLA2) and prediction of cardio-vascular risk among young Indian adults with dyslipidemia

Abstract

The study aimed to assess the role of lipoproteinassociated phospholipase A2 (Lp-PLA2) as an independent risk factor for cardiovascular diseases (CVD) in the young South Indian populations with dyslipidemia. Despite literature reporting the strong association of Lp-PLA2 with coronary artery disease (CAD), there is underreporting of the association of socio-demographic, behavioral, anthropometric and comorbid factors, particularly from regional contexts. Hence, the present study focused mainly on the young South Indian populations with specific inclusion and exclusion criteria. A cross-sectional study design was conducted among the subjects (n = 45 CAD and 40 controls), aged 18 and above. Socio-demographic and clinical characteristics and physical measurements like height, weight and abdominal circumference were recorded. Fasting plasma glucose, lipid profile, serum urea, creatinine and Lp-PLA2 were determined using the enzyme-linked assay method. Among the control and CAD participants, variables like age, type of occupation, marital status, history of diabetes, hypertension, dyslipidemia, physical activity, abdominal circumference and lipid profile were significantly different. Multivariate regression analysis showed that FBS (β 0.132, p 0.04), TGL (β 0.305, p 0.04), HDL-c (β -0.45, p 0.007) and creatinine (β 0.262, p 0.04) were significantly predicted by the level of LpPLA2. The findings of this study show an important association of abdominal adiposity, fasting blood glucose level and lipid profile with the level of Lp-PLA2. Lp-PLA2 can be considered as a novel risk marker for CAD among young Indians, based on the predictors identified in this study.