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Impact of YAQ001 on the Gut Microbiome, Permeability and Markers of Systemic Inflammation in Patients With Cirrhosis

Jin-Xia Liu F. Garcia-Guevara J. Macnaughtan Y. Jin Ainhoa Ferret-Miñana F. Clasen N. Yuen R. G. Maset J. Ramón-Azcón A. Kerbert T. Portlock Javier Martínez A. Habtesion A. Phillips F. De Chiara G. Ingavle T. Baldwin C. Jiménez G. Zaccherini K. Husi M. Rodríguez-Gandía P. Cordero-Sanchez J. Soeda J. Oben K. Church Jia V. Li A. Jalan A. Juanola E. Solà Simon Eaton C. Morgan T. Avery M. Kowalski D. Green A. Gander L. Edwards I. J. Cox H. Cortez-Pinto Reiner Wiest Francois Durand P. Caraceni R. Elosua Joan Vila Marco Pavesi V. Arroyo Nathan Davies R. Mookerjee S. Sandeman G. Mehta J. Marchesi Agustín Albillos Jennifer L. Rohn F. Andreola Saeed Shoaie R. Jalan
Oct 2026 · Liver international (Print) · Vol 46 · 0 citations · 49 references
Medicine

TL;DR

This substudy aimed to explore the effects of YAQ001 on the gut microbiome and their exploratory association with biomarkers of gut permeability and systemic inflammation.

Abstract

YAQ001 is a novel, non‐absorbable, gut‐restricted, multiporous, carbon bead adsorbent. Pre‐clinical studies and a clinical trial suggested its therapeutic potential and safety in patients with cirrhosis. This substudy aimed to explore the effects of YAQ001 on the gut microbiome and their exploratory association with biomarkers of gut permeability and systemic inflammation.

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