Aug 2026· Cell journal· Vol 28 1, pp.
1-14
· 0 citations
Medicine
TL;DR
Congenital hypothyroidism disrupts hormonal balance, increases oxidative stress, and induces ovarian histological alterations, and Treadmill training exerts protective effects, highlighting its potential as a non-pharmacological strategy that could mitigate reproductive complications associated with hypothyroidism.
ABSTRACT Objective The present study aimed to investigate lipolytic function in cumulus cells (CCs) from women with polycystic ovary syndrome (PCOS), with a particular emphasis on the role of androgen excess. Study Design Samples of follicular fluid and CCs were collected from 30 PCOS and 30 control subjects. Human pri...
Reza Zarezadeh, A. Fattahi, Kobra Hamdi et al.· Reproductive Medicine and Bi...· 0 citations
Pilot study results suggest potential miRNAs and their target pathway links with PCOS that need validation in larger cohorts for diagnostic or therapeutic applications need validation in larger cohorts for diagnostic or therapeutic applications.
A novel EDC-CBX2-H3K27me3 epigenetic axis that decouples GC proliferation from metabolic support functions is revealed, establishing CBX2 as both a molecular biomarker and potential therapeutic target for environment-associated PCOS.
Chan Zhu, Xian-Liang Qiu, Hong Yang et al.· Journal of Steroid Biochemis...· 0 citations
These findings provide a comprehensive characterization of glycolytic dysregulation in PCOS and identify GPT2 as a potential metabolic regulator linking altered energy metabolism to ovarian dysfunction, and provide a molecular framework for future studies investigating metabolism‐ and nutrition‐based intervention strat...
Findings indicate that PCOS and FHA represent fundamentally divergent metabolic states, with obesity acting as a key modifier of metabolic dysfunction in PCOS.
S. Nyunt, Thomas Hopkins, A. Le Guennec et al.· European Journal of Endocrin...· 0 citations
Findings support an association between endocrine alterations and inflammatory responses in ovarian GCs during PCOS, suggesting a potential hormone–inflammation interaction axis in the pathophysiology of PCOS.
Shao-Yu Hao, Jing Pan, Qi Zhao et al.· Journal of Ovarian Research· 0 citations
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