Hyp-retro: hypernetwork-guided preference-conditioned retrosynthetic planner.

Jing-Wen Wang Shuan Liu Shao-Ye Zhang Jian-Bo Qiao Guan-He Li Han-Jun Zhao Xiang-Xiang Zeng Jin-Jin Li Changhang Lin Chen Su Le-Yi Wei

Aug 2026 · Molecular diversity · 0 citations · 27 references

Medicine

TL;DR

Experimental results show that Hyp-Retro outperforms comparative methods in terms of search success rate and route yield, and it can adaptively adjust its planning strategy under different yield preferences, thereby generating high-quality retrosynthetic routes that better satisfy target-specific requirements.

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