A testable integrative model in which microvascular injury, blood-brain barrier disruption and neuroinflammation may contribute to persistent cognitive symptoms in PCS is outlined, as current data are largely cross-sectional and derive partly from in vitro work.
The conclusion that routine CSF abnormalities largely do not seem to reflect mechanisms specific to PCS is argued against routine CSF diagnostics as a source of disease-specific biomarkers in unselected PCS patients and support future studies focusing on alternative mechanisms underlying persistent neurological symptom...
D. Erhart, L. Balz, I. Giotaki et al.· medRxiv· 0 citations
Serum levels of growth differentiation factor 15, a mitochondrial stress marker, and vascular cell adhesion molecule-1, a vascular endothelial stress marker are evaluated in 32 patients with Long COVID who presented with persistent systemic or neurological symptoms and had not required acute-phase hospitalization to su...
Rie Ono, Shin Takayama, Michiaki Abe et al.· Frontiers in Medicine· 0 citations
The available evidence supports a multifactorial pathophysiological model involving viral persistence, immune dysregulation, autoimmunity, endothelial dysfunction, dysautonomia, and mitochondrial impairment, which is a heterogeneous multisystem condition involving neurological, respiratory, cardiovascular, musculoskele...
A. Clemente, Isabel Cristina, Correa Correa et al.· 0 citations
The available evidence regarding SARS-CoV-2 brain infection, induction of inflammation, coagulopathy, and blood–brain barrier (BBB) dysfunction as possible mechanisms underlying the disorders in the acute phase of COVID-19 disease and contributing to the development of neurodegenerative disorders in long COVID is analy...
Luiza Marek-Józefowicz, Alina Borkowska, B. Nedoszytko et al.· International Journal of Mol...· 1 citation
This study consists of an integrative literature review with an electronic search in the PubMed database, aiming to gather information and data established by the scientific community regarding the pathogenesis and development of neuropsychiatric sequelae in Post-COVID-19 Syndrome.
Gabrielle Pereira Damasceno, Sarah Romenia Souza Martins, C. D. de Cordova et al.· Revista de Estudos Interdisc...· 0 citations
PAS and PACVS exhibit substantial clinical and immunological overlap, including GPCR-directed autoreactivity and altered receptor-reactive T-cell responses, which suggest overlapping pathophysiological mechanisms.
J. Dinser, M. Anft, L. Wiemers et al.· medRxiv· 0 citations
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