This study shows that the conserved capsule gene CpsA is not strictly required for capsule attachment but instead works together with other LytRIZCpsAIZPsr (LCP) ligases, however, it requires the essential WalRK signaling system to maintain cell envelope integrity.
Findings support a model in which PL, PG, and LPS biosynthesis enzymes are engaged in a protein–protein interaction hub that synchronizes the production of all three layers of the Gram‐negative cell envelope in E. coli.
These findings provide the first evidence that the T7SS influences magnesium homeostasis and is essential for maintaining capsule integrity, both of which contribute critically to pathogenicity.
Fengyan Li, Chen Xu, Weiyi Ma et al.· Veterinary Research· 0 citations
The genomic context of three glycosyltransferase gene fragments (GT1-3) previously linked with dysbiotic states are resolved, and the CWPS locus is established as a mobile, structurally plastic element that directly influences cell wall architecture in L. crispatus.
P. Achterberg, M. Lekkerkerker, L. Koelemeijer et al.· Molecular Microbiology· 0 citations
Salmonella can assemble functional flagella, even when the acetylglucosaminidase activity of FlgJ is genetically inactivated, showing that early steps in flagellar assembly are more diverse than previously thought and that differences in cell wall structure between gram-positive and -negative bacteria likely determine...
Yann H. U. Chevance, M. Kinoshita, F. Chevance et al.· Journal of Bacteriology· 0 citations
Cryo-electron microscopy (cryo-EM) structures of the Pseudomonas aeruginosa MurA-LpxC complex in the absence and presence of the LpxC inhibitor CHIR-090 are determined, providing molecular insights into complex formation.
Joshua Yi Yeo, Xin-Fu Yan, Zhu Qiao et al.· Journal of Structural Biolog...· 0 citations
Sortase A (SrtA) enzymes covalently anchor surface proteins to Gram-positive bacterial cell walls, promoting colonization and virulence. In Streptococcus pneumoniae, previous studies identified both a domain-swapped dimer and an active refolded monomer, but the active enzyme has not been characterized at the structural...
Eunjeong Lee, Blaine H. Gordon, J. Redzic et al.· Biomolecules· 0 citations
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