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Open access Aug 2026

A genetic screen unveils key molecular steps in the polymerization cycle of the bacterial actin-like MreB

Key mechanistic steps coordinating ATP-driven MreB polymerization and turnover are established and provide a basis for a complete MreB assembly–disassembly cycle and for further elucidating how MreB dynamics contribute to cell-wall organization.

Alba de San Eustaquio-Campillo, C. Cornilleau, Sana Afensiss et al. · 0 citations
Open access Aug 2026

Actin filament assembly driven by distributive polymerases clustered on membrane surfaces.

It is concluded that surface-mediated polymerization can outpace solution-mediated elongation, even at high actin concentrations (>100 μM); the finite time required for profilin dissociation decreases the advantage conferred by surface-associated polymerases, but only in the absence of force.

R. D. Mullins, Jane Kondev, Kristen Skruber · 0 citations
Review Open access Sep 2026

Coordinated Arp2/3-mediated actin branching and myosin-dependent force generation in membrane–cytoskeleton remodeling

The Arp2/3 (Actin-Related Protein 2/3) complex nucleates branched actin networks, while myosin motors generate force and reorganize actin through ATP-dependent motor activity. Their coordination is central to membrane remodeling, but the underlying mechanisms differ substantially among cellular processes and organisms....

Chun-Zhen Jiang, Yi-Fan Li, Jiang-Hong He · 0 citations
Open access Jul 2026

Multiscale Conformational Dynamics of DNA Holliday Junctions Modulated by Ion Concentration: Insights from Fluorescence Correlation Spectroscopy and Time-Resolved Anisotropy.

By directly linking Mg2+-dependent structural compaction to microsecond-scale dynamics, this work reveals fundamental physical principles governing the behavior of recombination intermediates at the single-molecule level.

Chanchal Sharma, A. K. Upadhyaya, D. Sasmal · 0 citations
Review Open access Jul 2026

Curving Actin Across Systems: Do Axonal Actin Rings Share Common Underlying Mechanisms?

A comparative perspective uncovers shared design principles that may also apply to axons and offers a conceptual framework for dissecting the molecular basis of MPS nucleation, assembly, and long‐term stability.

A. R. Costa, Luís P. Rodrigues, Monica M. Sousa · 0 citations
Open access Aug 2026

Molecular orchestration of global actin remodelling by INF2

The findings uncover a novel product-inhibition mechanism that limits INF2 function and offer important insight into disease mechanisms linked to actin dysregulation.

Felix Uecker, Sven Wargenau, Micaela Boiero Sanders et al. · 0 citations

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