Skip to content
Log in
Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Design, Synthesis, Characterization and Evaluation of Anticancer Activity of Substituted-4-(Substitutedphenylhydrazon o)-3,4-Dihydroquinolin-2-(1H)-One

Swezel Negredo B. Biradar Soniya Phadte S. Shingade M. Katagi S. Desai P. Mali
· 0 citations · 12 references

TL;DR

The combined computational and biological data suggest that these hydrazinoquinoline derivatives, especially those with electron-withdrawing substituents, hold promise as lead structures for further development in liver cancer therapy targeting EGFR.

Semantic Scholar
View source

Similar papers

Open access Aug 2026

DESIGN, SYNTHESIS, AND PRELIMINARY ANTIPROLIFERATIVE EVALUATION OF BENZIMIDAZOLE-1,3,4-OXADIAZOLE HYBRIDS SHOWING PREFERENTIAL ACTIVITY IN BREAST CANCER CELL LINES

Findings indicate that the benzimidazole-1,3,4-oxadiazole hybrid scaffold may provide a useful starting point for the development of breast cancer-oriented antiproliferative candidates.

Mahmut Gozelle, Şevval Yaman, Züleyha Arslan et al. · 0 citations
Open access Sep 2026

Design, synthesis, molecular docking and anticancer activity of novel N-(4-(chlorodifluoromethoxy)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives

Results suggest that the N-(4-(chlorodifluoromethoxy)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide scaffold is a useful template for designing selective BCR-ABL1-directed anticancer agents, with compound 9c as an encouraging lead for further optimisation and mechanistic studies.

Pradeep B. Bhise, Sandeep B. Bhise, Somnath Dasgupta et al. · 0 citations
Jul 2026

Design, robust synthesis, and anti-liver cancer activity of 2-hydrazono-5-acetyl-[1,3,4]thiadiazole and N'-ethylideneethanethiohydrazide derivatives: In vitro, gene expression, DNA damage, and DNA fragmentation.

A novel series of 2-hydrazono-5-acetyl-[1,3,4]thiadiazole and N'-ethylideneethanethiohydrazide derivatives tested as anticancer agents against a panel of cancer cell lines, and the mechanism of action of the most active compounds against liver cancer was explored through gene expression, DNA damage, and DNA fragmentati...

Ashraf A. Sediek, Eman Sabry, Huda F. Khalil et al. · 0 citations
Aug 2026

Design, synthesis and dual anticancer and antibacterial evaluation of novel 1,3,4-oxadiazole-2-thiol derivatives targeting EGFR and DNA Gyrase B: integrated docking, DFT and ADMET studies.

1,3,4-oxadiazole-2-thiol derivatives are established as promising dual-action therapeutic scaffolds for anticancer and antibacterial activities through computational and experimental approaches.

Ila M. Ram, Jay B. Maheta, Darshna K. Lakhnotra et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.