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Urea and carbamate-functionalized quinazolin-2,4-dione derivatives as EGFR tyrosine kinase inhibitors: synthesis, anticancer evaluation, molecular docking and molecular dynamics studies

Mohamed El-Naggar Fawzy Abdelshafy A. Mosallam Abdelfattah Hassan Aboubakr H. Abdelmonsef
Aug 2026 · Journal of Computer-Aided Molecular Design · Vol 40 · 0 citations · 31 references
Medicine

TL;DR

Two novel classes of hybrid quinazolin-2,4-diones 2–17, privileged with urea and/or carbamate moieties, as EGFR-TK inhibitors represent promising lead candidates for developing novel EGFR inhibitors for cancer treatment.

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