Current knowledge on the structural features of herpesvirus tegument proteins are summarized, highlighting the structure-based functional implications, including their potential as targets for antiviral drug development.
Current understanding of the interaction between letermovir and the HCMV terminase is summarized, focusing on structural organization, inhibitory mechanisms, resistance mutations, and emerging approaches for next-generation inhibitor development, and highlighting key unresolved questions that will guide future structur...
Guo-Jun Chen, Yu-Qi Li, Jin-Rui Chen et al.· Frontiers in Microbiology· 0 citations
The past and recent genetic, biochemical, and structural research on viral terminase motors that has illuminated their role in DNA packaging and potential as candidates for antiviral drug targeting are discussed.
Makayla N. Leroux, C. Teschke· Journal of Virology· 0 citations
This work reviews the current evidence on PTMs in orthoflavivirus C proteins and integrates insights from studies of other RNA viruses to propose mechanisms by which PTMs may regulate C protein function, and identifies conserved regulatory hotspots that represent promising targets for future experimental validation.
N. C. Mebus-Antunes, Dayane Henriques, A. D. Da Poian· Molecules· 0 citations
Human coronaviruses include both endemic respiratory pathogens and highly pathogenic viruses with pandemic potential, underscoring the need for antiviral agents with activity beyond single viral species. This review focuses on selected, representative antiviral inhibitors directed against viral proteins of human corona...
Álvaro de la Cruz-Potenciano, Miguel Maldonado, M. Camarasa et al.· ChemMedChem· 0 citations
A high-resolution map of host-driven PTMs on ZIKV proteins as well as cellular interacting kinases are defined, novel mechanisms of host driven-regulation of ZIKV particle release and cytopathogenicity are uncovered, and an FDA-approved inhibitor of ZIKV growth is identified.
I. Manuelyan, Anna M. Schmoker, B. Yount et al.· PLoS Pathogens· 0 citations
A comparative study through a combination of experimental NMR and computational methods to structurally characterize the interaction occurring between ZO1-PDZ2 and three peptides mimicking the C-terminal PBM of E protein from SARS-CoV (now SARS-CoV-1), SARS-CoV-2, and MERS-CoV.
A. Toto, V. Pennacchietti, Carla Isernia et al.· The FEBS Journal· 0 citations
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