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Open access Sep 2026

527. Chronic stress induces region- and cell-type-specific changes in GABAA receptor α-subunit expression in mice

The region- and cell-specific expression of α1, 2, 3, 4, and 5-containing GABAA receptors in a mouse model of chronic stress suggested region- and cell-specific changes to GABAergic signaling caused by stress, potentially explaining pathology and response to GABA-targeting treatments.

T. Prévot, C. Marceau-Linhares, J. Chiella et al. · 0 citations
Open access Aug 2026

Sex-Specific Organization and Synaptic Signaling in Prefrontal-Hypothalamic Circuitry

Overall, PH neurons were more excitable in females compared with males, and, in both sexes, data indicated tonic inhibition within the PH, with significantly greater inhibition in males.

C. Bouchet, E. Pinsinski, Julia C. Cook et al. · 0 citations
Open access Sep 2026

GPR55 deletion increases anxiety- and depression-like behaviors and modifies amygdalar GABAAα2 expression

Findings indicate that loss of GPR55 heightens emotional vulnerability and alters specific GABAergic markers in the AMY while preserving HPA axis-related transcriptional response to acute stress and support GPR55 as a potential target for the modulation of anxiety- and depression-related states.

M. García-Gutiérrez, Lucía Illescas, A. Gasparyan et al. · 0 citations
Review Open access Aug 2026

The role of the anterior cingulate cortex in anxiety control, from circuits to disorders

A timely and comprehensive view of the anterior cingulate cortex’s role in adaptive and pathological anxiety is provided and an integrative model in which ACC effects depend on subregion, projection target, and behavioral context is proposed.

Emily Dew, Alexis Jones, S. Saggu et al. · 0 citations
Open access Sep 2026

Distinct CaMKII neurons in anterior cingulate cortex regulate anxiety-like behavior and appetite suppression in a model of inflammatory pain

Two distinct CaMKII neurons in the anterior cingulate cortex are identified: one that projects to the basolateral amygdala (BLA) and is associated with anxiety-like behavior and another that projects to the nucleus accumbens (NAc) and regulates appetite suppression.

Jian-Dong Yu, Hui-Yue Han, Yue-Han You et al. · 0 citations
Open access Sep 2026

512. Oxytocin-receptor neurons in mPFC in stress-induced anxiety behaviors

It is identified that Oxtr in the mPFC modulates anxiety-like behaviors primarily by impairing mitochondrial ATP production and Ornithine metabolomics pathway.

D. Shi, Z. Wang · 0 citations

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