Aug 2026· Microchimica Acta· Vol 193· 0 citations· 35 references
Medicine
TL;DR
A straightforward, rapid, and highly sensitive biosensor has been developed for the detection of doxorubicin (DOX) in human serum samples, achieving a low detection limit of 0.029 µM.
Abstract
Arginine surface-engineered 6-aza-2-thiothymine gold nanoclusters (Arg/ATT-AuNCs) via host-guest assembly were synthesized which exhibit exceptional catalytic activity and intense photoluminescence. Arg/ATT-AuNCs enhanced the CL intensity from NaIO4-H2O2 system by 1200-fold. The CL mechanistic studies revealed that Arg/ATT-AuNCs not only accelerated decay of H2O2 to form reactive oxygen species, but also acted as efficient energy acceptors of singlet oxygen (1O2) via a CL resonance energy transfer (CRET) pathway. It was observed that doxorubicin (DOX) quenches the CL signal through an inner filter effect that disrupts the CRET process. Based on this, a straightforward, rapid, and highly sensitive biosensor has been developed for the detection of DOX in human serum samples, achieving a low detection limit of 0.029 µM. The biosensor was applied to DOX determination in human serum samples with recoveries ranging from 91.1 to 106.2%. This study not only provides a new method for the detection of DOX, but also broadens the application scope of AuNCs in the field of CL.
Sensitive and accurate monitoring of arginase activity is significant for clinical diagnosis. Herein, a dual-enhanced aggregation-induced electrochemiluminescence (ECL) biosensor was constructed based on triple-ligand-protected gold nanoclusters (AuNCs), sequentially coating 6-aza-2-thiothymine-capped AuNCs with L-argi...
Li-Li Tong, Xue-Ke Luo, Yan Zhang et al.· In Analysis· 0 citations
A fluorescence-based sensing platform has been developed for the ultrasensitive detection of H2S using an aggregation-induced emission (AIE) active dicyanoisophorone derivative with o-vanillin (DSVL) and shows improved sensitivity with the detection limit down to 0.86 nM.
Rajanee Nakum, Suban K. Sahoo· Chemistry - An Asian Journal· 0 citations
Herein, silver nanoclusters (FO-Ag NCs) were synthesized using folic acid and O-phenylenediamine as ligands, with an emission at 578 nm when excited at 410 nm. The FO-Ag NCs achieved multivariate determination for Hg2+ and bovine serum albumin (BSA) via two strategies. Initially, Hg2+ quenched the emission, while BSA e...
Qing-Qing Peng, Wei Tang, Siqi Chen et al.· Journal of Agricultural and...· 0 citations
Gold nanostructures with branched morphologies exhibit strong plasmonic properties, enabling advanced biosensing and biochemical applications. Here, we report a rapid and scalable synthesis of gold nanoflowers (AuNFs) using modified benzenethiols as both reducing and capping agents. Benzenethiols bearing electron-donat...
Jin-Ho Park, Young Kwan Cho, Victoria L. Schaal et al.· Small· 0 citations
Kanamycin (Kana) residues released into aquatic environments due to its extensive use have raised increasing concerns because of their potential risks to ecosystems and human health. In this work, we report a label-free split aptamer-modified gold nanoflower (AuNF)-based aptasensing platform with colorimetric and elect...
Hailiang Qin, Xin-Yang Guo, Yao Zhao et al.· Talanta: The International J...· 0 citations
The sensitive and selective detection of nucleoside biomarkers is crucial for the early diagnosis and monitoring of various physiological and pathological conditions. In this work, polyaniline (PANI)/MXene quantum dot (MQD) nanohybrids were developed as an electrochemical sensing platform for the detection of the bioma...
Aafreen Nakai, Rijo Rajeev, Manoj B. Sariga et al.· Physical Chemistry, Chemical...· 0 citations
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