It is demonstrated that decreased serum BDNF levels are associated with the presence and symptom severity of anxiety disorders, and the Val66Met polymorphism does not appear to be a primary determinant of serum BDNF levels in this population, suggesting that other genetic or environmental factors may be involved.
BDNF Val66Met polymorphism was significantly associated with clinical symptom severity, cognitive function, and treatment-related improvement among Acehnese individuals with schizophrenia, and the Val/Val genotype was associated with a more favorable clinical and cognitive profile and stronger early clinical and cognitive response.
ABSTRACT Background and Aims Bipolar disorder (BD) is a severe mood disorder with unclear pathogenesis and limited diagnostic biomarkers. This study aimed to evaluate serum levels of BDNF, mBDNF, AQP4, proBDNF, and GSK3β between BD patients and healthy controls, and to preliminarily explore their potential clinical significance. Methods Thirty‐seven patients admitted to the Affiliated Hospital of Hangzhou Normal University with BD from November 2023 to September 2025 were selected as the study subjects, while 36 healthy blood donors from the Affiliated Hospital of Hangzhou Normal University, collected in April 2025, were selected as the control subjects to compare serum biomarkers levels of the two groups. Receiver operating characteristic (ROC) curves were plotted to evaluate the diagnostic value of serum biomarkers levels for bipolar disorder. Correlations between serum biomarkers were analyzed between the two groups. Results The results revealed lower levels of BDNF and AQP4 and higher levels of mBDNF, proBDNF and GSK3β in the BD group compared to the healthy control group. Positive correlations were observed between serum BDNF and proBDNF, mBDNF and AQP4, as well as mBDNF and GSK3β levels in the BD group. Combining the serum biomarkers improved diagnostic accuracy compared to using individual serum biomarkers alone. Conclusion In conclusion, patients with BD exhibit elevated serum levels of proBDNF and GSK3β compared to healthy controls, while the levels of BDNF, mBDNF, and AQP4 are significantly lower. These findings suggest that this serum biomarker panel may hold preliminary potential as a supportive indicator for BD. However, given the study's cross‐sectional design and lack of external validation, larger longitudinal cohorts are required to further evaluate its potential clinical significance.
Jiawei Zhou, Chunying Zhu, Juezhuo Li et al.· Health Science Reports· 0 citations
Background: Major depressive disorder (MDD) has been
increasingly recognized as a systemic disorder involving
neuroimmune and biochemical dysregulation. Circulating neurotrophic factors, particularly nerve growth factor
(NGF), may serve as potential laboratory biomarkers reflecting neurobiological alterations.
Methods: This case–control study enrolled 47 drug-naïve
patients with first-episode MDD and 40 age- and sexmatched healthy controls. Serum NGF concentrations
were quantified using enzyme-linked immunosorbent assay (ELISA). The NGF Ala273Val (rs6330) polymorphism
was genotyped via polymerase chain reaction and direct
sequencing. Statistical analyses included group comparisons, correlation analysis, and genotype–phenotype association evaluation.
Results: Serum NGF levels were significantly elevated
in patients with MDD compared with controls (36.81 ±
7.11 vs. 29.74 ± 5.69 pg/mL, P < 0.001). However, no
significant correlation was observed between NGF concentrations and HAMD-17 scores (r = 0.12, P = 0.42).
Genotype and allele distributions of the NGF Ala273Val
polymorphism did not differ significantly between groups
(P > 0.05), and no genotype-dependent differences in
serum NGF levels were detected. Conclusion: Circulating NGF is significantly altered in
first-episode MDD, supporting its role as a neuroimmunerelated biochemical marker associated with disease
presence rather than symptom severity. The NGF
Ala273Val polymorphism does not appear to influence
susceptibility or peripheral NGF expression. These
findings highlight the potential utility of serum NGF as a
laboratory biomarker in the biochemical characterization
of MDD.
Lian Liu, P. Xiong, Yong Zeng· Journal of Medical Biochemis...· 0 citations
The inverse relationship between BDNF and S100 B suggests a link between neurotrophic and neuroinflammatory processes and nursing interventions that enhance BDNF may also affect S100 B level, which may foster brain health in older adults.
Ryuzo Orihashi, Takumi Shiraishi, Toru Murakawa-Hirachi et al.· Biological Research for Nurs...· 0 citations
