TL;DR
It is suggested that CYPs potentially improve the immune-related indicators in CTX-induced immunosuppressed mice, accompanied by changes in immune organ integrity, gut microbiota composition, and host metabolic pathways.
It is highlighted that Mannatide is associated with immune recovery in CTX-treated mice, accompanied by changes in gut microbiota, SCFA production, and immune-related signalling pathways, and provide insights for adjuvant therapies targeting the gut-immune axis.
Introduction Immunosuppression induced by chemotherapeutic agents such as cyclophosphamide (CTX) is frequently associated with gut microbiota dysbiosis. Sanghuangporus sanghuang polysaccharide (SSP1) possesses immunomodulatory potential; however, its effects on mucosal immunity and the gut microbiota remain unclear. Me...
The present findings suggest that HAMSIAA is a promising functional food ingredient for the prophylactic mitigation of chemotherapy induced immunosuppression, and provide support for its translational application in the field of immunonutrition.
Alfalfa polysaccharide fraction II (APS-II) exerts a protective effect on mice with CTX-induced immunosuppression, laying the scientific foundation for its development as an immunomodulatory ingredient in functional foods and dietary supplements.
Findings support the dual potential of AMLF in functional foods and as immunomodulatory adjuvant in functional foods and as immunomodulatory adjuvants.
BACKGROUND AND PURPOSE This study investigated the therapeutic effects and gut-liver axis-related mechanisms of tetramethylpyrazine (TMP) in metabolic dysfunction-associated steatohepatitis (MASH). EXPERIMENTAL APPROACH Male C57BL/6 mice were fed a methionine- and choline-deficient (MCD) diet for 6 weeks to establish...
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