TL;DR
This comprehensive review on Nanotechnology focuses on the entire spectrum of ovarian cancer management and recent advances in physicochemical properties, PK/BD, diagnostic biosensors, treatment modalities to reverse MDR, immunomodulation and personalized nanomedicine are summarized.
Overall, cancer nanomedicine has evolved from a simple drug-delivery concept into a multifunctional therapeutic platform integrating targeted therapy, molecular imaging, immunomodulation, gene therapy, and personalized medicine.
PEGylation has been shown to extend the circulatory lifetime, enhance drug deposition in tumors, and minimize off-target toxicity, and more effective design solutions should be employed, including stimuli-responsive liposomes and patient-tailored methods.
Novel NCs like microemulsions, vesicular (liposomes), and nanoparticular NCs are created and explored, which have unique improved penetration and retention in the tumour tissue.
This review evaluates diverse nanoparticle-based delivery systems and their targeting mechanisms in natural product-based breast cancer therapy and concludes that natural products possess potent anti-breast cancer effects, and the application of nanodelivery technology effectively overcomes their inherent limitations o...
Theranostic nanomedicine integrates diagnostic and therapeutic functions into a single nanoparticle, allowing clinicians to image a tumor and treat it with the same agent, and regulators have not agreed on how to classify combination nano-diagnostic-therapeutic products, so approval pathways are unclear.
A translational framework for overcoming key barriers in pharmaceutical intervention design for oncology applications is outlined, integrating drug delivery engineering, molecular biopharmaceutics, and computational optimization.
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