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Parietal Cortex Transcriptomics Refines Parkinson Disease GWAS Nomination and Highlights STAT3 as a Putative Upstream Glial Regulator

Isabel Alfradique-Dunham Jessie Sanford Meng-Han Liu R. Perrin Erin E. Franklin S. Norris Paul T. Kotzbauer J. Perlmutter John Budde C. Cruchaga Laura Ibañez Miguel A. Minaya
Aug 2026 · bioRxiv · 0 citations · 77 references
Biology Medicine

TL;DR

It is suggested that integrating disease-state transcriptomics with genetic prioritization can refine PD risk-gene nomination and uncover regulatory programs that may be missed by GWAS alone.

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