It is revealed that ensemble composition directly affects the precision-recall trade-off: heterogeneous cross-paradigm ensembles generally improve precision, whereas homogeneous LLM ensembles more often achieve higher overall F1-scores.
Abstract
Ontology alignment (OA) has evolved through several methodological paradigms, ranging from lexical and structural aligners to knowledge graph embedding (KGE) models and, more recently, Large Language Model (LLM)-based approaches. Although modern OA frameworks provide unified ecosystems for deploying these heterogeneous aligners, mechanisms for systematically reconciling their complementary and sometimes conflicting predictions remain relatively underexplored. We present OntoAligner-Ensemble, a modular and aligner-agnostic framework that combines candidate correspondences through a configurable two-stage process comprising voting-based fusion strategies followed by post-fusion selection policies. The framework supports any aligner implemented within OntoAligner that produces candidate correspondences, enabling diverse alignment paradigms to be integrated through a unified decision process. To demonstrate its effectiveness, we instantiate the framework using representative lightweight string-aligner, KGE-based, and Retrieval-Augmented Generation aligners powered by both open-weight and API-based LLMs. We evaluate individual aligners and ensemble configurations across eight benchmark tasks from five OAEI tracks spanning biomedical to beyond-equivalence. The results show that ensemble fusion consistently improves the balance between precision and recall and frequently outperforms standalone aligners across diverse domains. Furthermore, our analysis reveals that ensemble composition directly affects the precision-recall trade-off: heterogeneous cross-paradigm ensembles generally improve precision, whereas homogeneous LLM ensembles more often achieve higher overall F1-scores. These findings demonstrate that systematic ensemble learning offers a robust and reproducible strategy for OA while providing practical guidance for selecting ensemble compositions under different alignment scenarios.
OntologyAligner is presented, a three-stage framework that combines ontology-aligned retrieval, large language model candidate reranking, and selective hierarchy-guided refinement that offers a generalizable framework for accurate mapping of biomedical text to structured ontology concepts.
Jie Song, Zhi-Chuan Xu, Zi-Yue Lu et al.· 0 citations
This paper addresses the placement of concepts that are absent from the target ontology—the out-of-knowledge-base setting—in which a textual mention must be assigned one or more insertion positions in the subsumption hierarchy rather than linked to an existing node.
Zhanna B. Sadirmekova, M. Sambetbayeva, B. Abdygalym et al.· Information· 0 citations
Constructing typed, justified semantic links between ontologies is essential for enabling interoperability across heterogeneous and interdisciplinary knowledge domains. However, manually curating such links is difficult to scale. To address this challenge, we propose an end-to-end framework for ontology network constru...
It is indicated that the evaluated embedding and reranking configurations do not reliably recover the compatibility encoded by the selected ontology relations and phenotype combinations and motivate retrieval systems that better integrate learned representations with structured biomedical knowledge.
Xiao Yu Cindy Zhang, W. Wasserman, Jian Zhu· 0 citations
LAMP (LLM-Assisted Mapping Pipeline), a novel approach that leverages Large Language Models (LLMs) to assist the mapping process in OBDI, is introduced, demonstrating significant improvements in F1-scores–particularly in complex mapping scenario–compared to single-prompt approach.
Sulthoni Ashiddiiqi, Fajar J. Ekaputra, M. Zuhri et al.· 1 citation
A novel unsupervised entity alignment framework, named LLM‐Align, is presented to effectively leverage Large Language Models to precisely annotate entity pairs, which alleviates structural heterogeneity between aligned entities.
Zhi-Huan Yan, Yi Wang, Chong-Chong Zhang et al.· Expert systems· 0 citations
Machine-learning networks can learn without detailed instructions from a designer. Those that do may offer insight into how the brain reorganizes itself during learning.
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