Aug 2026· Zeitschrift für Induktive Abstammungs- und Vererbungslehre· Vol 301· 0 citations· 46 references
Medicine
TL;DR
A specific mechanism whereby HOXC9 transcriptionally activates NRP1 is elucidated, thereby contributing to CRC malignant development and immune evasion and elucidate a specific mechanism whereby NRP1 overexpression could reverse CRC progression inhibition and immune function enhancement caused by HOXC9 downregulation.
Colorectal cancer (CRC) is a common cause of cancer-related deaths worldwide. Electron transfer flavoprotein dehydrogenase (ETFDH) is a novel prognostic biomarker for human CRC. However, the role and molecular mechanism of ETFDH in CRC are still unclear. DEGs in CRC development were identified using mRNA microarray dat...
Yan Zeng, Qiao-Zhen Liu, Ya-Li Xu et al.· General Physiology and Bioph...· 0 citations
GATA2 inhibits EMT, invasion, and migration in UCEC by transcriptionally activating the ZNF486-JAM2 axis and provides a potential molecular framework for understanding UCEC progression.
Xing Fan, Zheng-Jia Tong, Ying-Xia Ou et al.· Frontiers in Oncology· 0 citations
A potential mechanism by which HOXC9 contributes to ESCC progression via AKT/mTOR-mediated inhibition of mitochondria-dependent apoptosis and promotion of cell proliferation is identified.
Xin-Ya Yu, Ya-Jun Wang, Xin-Yue Ju et al.· Molecular and Cellular Bioch...· 0 citations
BACKGROUND
Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of renal cancer and remains associated with aggressive progression and poor clinical outcomes. Cartilage intermediate layer protein 2 (CILP2), an extracellular matrix-associated secreted protein, has been implicated in tumor-rela...
Jia-Jia Sun, Tong-Zhen Yan, Zi-Yuan Zhang et al.· Pathology, Research and Prac...· 0 citations
It is suggested that lnc-DNAJC3-AS1 promotes GC progression, at least in part, through the miR-576-5p/LYPLA1 pathway, providing a potential target for GC treatment.
Zhen-Ni Sun, Ya-Sai Yao, Zhi-Jian Xu et al.· American Journal of Cancer R...· 0 citations
Clinically, these findings identify the METTL1/USP48/LCN2 pathway as a potential therapeutic target for cSCC and elucidated a novel oncogenic axis in cSCC, wherein METTL1 stabilized USP48 mRNA through m7G methylation modification, and USP48 in turn deubiquitinated and stabilized LCN2 protein.
Xiu-Qi Li, Lin Shu, Xiao-Qiang Li et al.· Applied Biochemistry and Bio...· 0 citations
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