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Depressive symptom heterogeneity and mortality in a prospective U.S. cohort

Aug 2026 · European Archives of Psychiatry and Clinical Neuroscience · Vol 276, pp. 3995 - 4006 · 0 citations · 25 references
Medicine

TL;DR

Examining PHQ-9 total score, affective and somatic domains, and individual items in relation to all-cause, heart disease, and non-cardiac mortality using survey-weighted Cox models suggested symptom-level heterogeneity, but item-level modeling did not meaningfully improve discrimination.

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