This review demonstrates the regulatory effects of resveratrol on cellular signaling pathways linked to NDs and its neuroprotective mechanisms and critically compare evidence from preclinical and clinical studies, demonstrating both therapeutic potential and translational limitations.
The natural flavonoid Astragalin concurrently addresses three core pathological processes in PD, namely dopaminergic neuron degeneration, α-synucleinopathy, and neuroinflammation, through coordinated modulation of interconnected molecular pathways.
Jun Wang, Jie-Yu He, Qin Huang et al.· Free Radical Biology & Medic...· 0 citations
Terpenoids have the potential to be developed as novel multitarget neurotherapeutic agents with further research to bridge preclinical promise and clinical validation, and structural optimisation and advanced delivery systems, such as nanoparticles, cyclodextrin inclusion, combined therapeutic strategies, precision-tar...
Nidhi Gairola, Sushmita Uniyal, Jaya Martolia et al.· Mini-Reviews in Medical Chem...· 0 citations
The structural and catalytic features of SIRT1 are summarized, the mechanisms linking SIRT1 to cognitive impairment across major neurodegenerative diseases are examined, and the opportunities and limitations of SIRT1‐targeted therapeutic strategies are evaluated.
Jia-Bin Duan, Jia-Qiang Liu, Qing-Sheng Meng et al.· The FASEB Journal· 0 citations
Overall, natural products represent promising candidates for managing neurogenesis and neuroplasticity in AD, although further clinical studies are required to validate their therapeutic efficacy.
A. Shaheen, Mou-Sa A. Mai, Merhan O. Hindam et al.· Frontiers in Pharmacology· 2 citations
NAR has demonstrated the ability to reduce amyloid-β plaque deposition, inhibit α-synuclein aggregation, preserve dopaminergic neurons, modulate immune responses in multiple sclerosis, and improve functional recovery after spinal cord injury.
Nista Gurung, Ganesh Bohara, Nikesh Rimal et al.· Molecular Nutrition & Food R...· 0 citations
This review comprehensively examines the neuropharmacology of key secondary metabolites, including huperzine A, curcumin, resveratrol, epigallocatechin gallate (EGCG), and ginsenosides, focusing on their mechanisms against neurodegeneration, and critically evaluates evidence for neuroprotection through acetylcholineste...
Moses Okpata Chukwuebuka· Global Journal of Research i...· 0 citations
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