Skip to content

Toxicological Effects of Propyl 4-Hydroxybenzoate on Gallstone Pathogenesis: An Integrated Mendelian Randomization, Network Toxicology, and Experimental Study.

Aug 2026 · Food and Chemical Toxicology · pp. 116337 · 0 citations
Medicine

TL;DR

PP is highlighted as an environmental risk factor for gallstones, providing novel insights into their prevention and targeted therapy, and its role in gallstone pathogenesis remains unclear.

View source

Similar papers

Open access Aug 2026

Bisphenol A exacerbates dry eye disease via the CASP1/GSDMD-mediated pyroptotic axis: network toxicology, mendelian randomization, and experimental validation

It is suggested that CASP1 is a central molecular component in dry eye disease pathogenesis and inhibition of CASP1 effectively abrogates this process, suggesting potential avenues for clinical intervention.

Ying-cheng Wang, Chen-Hong Jiang, Yu Zhang et al. · 0 citations
Jul 2026

Toxic effects and mechanisms of methyl 4-hydroxybenzoate in allergic rhinitis: a multi-omics and toxicology study

Bioinformatics analyses suggest that MeP is correlated with AR development, and this correlation may involve the modulation of ESR2, IL2, and SLC3A2, as well as influences on immune cell infiltration and related signaling pathways.

Tian-Tian Wang, Wen-Qian Xu, Hui Wang · 0 citations
Open access Aug 2026

Exploring the Molecular Mechanisms by Which DEHP Promotes the Occurrence and Progression of Kidney Stones Based on Network Toxicology and Experimental Validation

Findings provide mechanistic evidence linking DEHP exposure to kidney stone pathogenesis by disrupting apoptosis–autophagy homeostasis in renal tubular epithelial cells.

Yongqi Wang, Jian-Qiao Pu, Yang Xun et al. · 0 citations
Open access Aug 2026

Integrating Network Toxicology and Untargeted Metabolomics to Identify Candidate Mechanisms and Metabolic Markers of α-Amanitin-Induced Hepatorenal Injury in Mice

Analysis of plasma from α-amanitin-poisoned mice preliminarily reveals that plasma metabolites follow a temporally dynamic progression across seven different groups, which is consistent with the toxicological injury–response–adaptation model.

Haiyan Cui, Yue Guo, Wang Xin et al. · 0 citations
Open access Aug 2026

FTO-mediated m6A modification suppresses acute pancreatitis by downregulating 1,2-dilinoleoyl-GPC (18:2/18:2): An integrated multi-omics mechanistic study.

It is found that FTO may promotes phospholipid metabolic reprogramming by stimulating an m6A-dependent posttranscriptional mechanism, which further inhibited disease development and provided new insights into the process of AP and new directions for targeted therapy.

Huan Liang, Geng-Hong Su, Shengjie Zheng · 0 citations
Open access Sep 2026

Exploring the targets and mechanisms of 6PPD-Q-induced cardiotoxicity: A network toxicology and molecular docking study.

6PPD-quinone (6PPD-Q), a transformation product of the tire antioxidant 6PPD, is an emerging traffic-related contaminant with well-documented ecotoxicity in aquatic species. Its recent detection in airborne particulate matter, road dust, and human urine has raised concerns about possible human health effects. However,...

Ai-Mei Lu, Kai-Lin Huang, Meng-Fan Li et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.