Toxicological Effects of Propyl 4-Hydroxybenzoate on Gallstone Pathogenesis: An Integrated Mendelian Randomization, Network Toxicology, and Experimental Study.
Aug 2026· Food and Chemical Toxicology· pp.
116337
· 0 citations
Medicine
TL;DR
PP is highlighted as an environmental risk factor for gallstones, providing novel insights into their prevention and targeted therapy, and its role in gallstone pathogenesis remains unclear.
It is suggested that CASP1 is a central molecular component in dry eye disease pathogenesis and inhibition of CASP1 effectively abrogates this process, suggesting potential avenues for clinical intervention.
Ying-cheng Wang, Chen-Hong Jiang, Yu Zhang et al.· Frontiers in Pharmacology· 0 citations
Bioinformatics analyses suggest that MeP is correlated with AR development, and this correlation may involve the modulation of ESR2, IL2, and SLC3A2, as well as influences on immune cell infiltration and related signaling pathways.
Findings provide mechanistic evidence linking DEHP exposure to kidney stone pathogenesis by disrupting apoptosis–autophagy homeostasis in renal tubular epithelial cells.
Yongqi Wang, Jian-Qiao Pu, Yang Xun et al.· International Journal of Gen...· 0 citations
Analysis of plasma from α-amanitin-poisoned mice preliminarily reveals that plasma metabolites follow a temporally dynamic progression across seven different groups, which is consistent with the toxicological injury–response–adaptation model.
Haiyan Cui, Yue Guo, Wang Xin et al.· Metabolites· 0 citations
It is found that FTO may promotes phospholipid metabolic reprogramming by stimulating an m6A-dependent posttranscriptional mechanism, which further inhibited disease development and provided new insights into the process of AP and new directions for targeted therapy.
Huan Liang, Geng-Hong Su, Shengjie Zheng· Medicine· 0 citations
6PPD-quinone (6PPD-Q), a transformation product of the tire antioxidant 6PPD, is an emerging traffic-related contaminant with well-documented ecotoxicity in aquatic species. Its recent detection in airborne particulate matter, road dust, and human urine has raised concerns about possible human health effects. However,...
Ai-Mei Lu, Kai-Lin Huang, Meng-Fan Li et al.· Ecotoxicology and Environmen...· 0 citations
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