Jul 2026· Journal of Biochemistry (Tokyo)· 0 citations
Medicine
TL;DR
Investigation of the formation and quantitative significance of Nω-(carboxyethyl)arginine (CEA), an underexplored MGO-derived arginine adduct indicates that CEA is a reliable marker for evaluating MGO-mediated protein degeneration and dicarbonyl stress in vitro and in vivo.
These findings highlight plumbagin as a potent multifunctional compound capable of mitigating MGO-induced glycation, and highlight plumbagin as a potent multifunctional compound capable of mitigating MGO-induced glycation.
Faiza Iram, Ayesha Aiman, Deepanshi Vijh et al.· Journal of Cellular Biochemi...· 0 citations
It is found that an elevated CEdG adduct burden is associated with increased DNA strand breaks, whereas increased CEG modifications are associated with reduced translational efficiency and mechanistically link metabolic stress-derived chemical lesions to genome instability and translational dysfunction.
Alana Battad, Francisco Núñez, S. Lai et al.· Chemical Research in Toxicol...· 0 citations
It is proposed that routine parameters such as gamma-glutamyl transferase and red cell distribution width may serve as accessible proxies for MGO burden, with the explicit caveat that these mappings require prospective validation and do not constitute a validated clinical instrument.
It is demonstrated that NAC effectively attenuates d‐ribose‐induced glycation and protein aggregation in vitro and provides mechanistic insights into its anti‐glycation properties through multiple complementary biochemical mechanisms.
R. Nabi, Tabrez Faruqui, M. S. Khan et al.· IUBMB Life - A Journal of th...· 0 citations
This competitive ELISA enables high-throughput quantification of MG-H1 in serum and demonstrates analytical feasibility; further multicenter validation is required before clinical implementation.
Jun Nojima, Masatsuna Tasaka, H. Fujigaki et al.· Diagnostics· 0 citations
Collective evidence from isotope tracing as well as genetic, dietary, and pharmacological manipulation experiments uncovered that C3-iminylation originates from cytochrome P450 (CYP)-mediated oxidation of omega-3 fatty acids, enabling further exploration of their biological and clinical implications.
Bing-Sen Zhang, Yu-Heng Hsieh, Tyler R. Bales et al.· Proceedings of the National...· 1 citation
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