Overall, available evidence suggests that MSCs may support neural function and repair through neurotrophic, anti-inflammatory, immunomodulatory, and regenerative mechanisms, but current clinical evidence remains limited and heterogeneous.
Mohammed S. Al-lami, Zainab Alnaji, E. Mohammed· International Journal of Hem...· 0 citations
This review critically discusses current developments, ongoing clinical trials, therapeutic mechanisms, and key challenges associated with stem cell-based interventions, and translational barriers that must be addressed for the successful clinical implementation of stem cell therapies in neurodegenerative diseases.
Sujatha Krishnamoorthy, Vibhusha Venkatesan, Urbi Roy· Journal of Sustainable Chemi...· 0 citations
This review traces the historical evolution of regenerative therapies for NDDs - from early exploratory cell transplantation to modern approaches involving pluripotent stem cells (PSCs) and in vivo direct reprogramming and elucidate the core strategies of regenerative medicine within an integrated framework encompassin...
Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system (CNS) characterized by focal demyelinating lesions throughout CNS. Current treatments for MS primarily target the immune system and are efficacious during the early phase of MS. Current MS treatments are largely ineffective at all...
Multiple Sclerosis (MS) is a chronic immune-mediated neurodegenerative disorder of the Central Nervous System (CNS) that affects more than 2.8 million people worldwide. It is recognized as one of the leading causes of non-traumatic neurological disability among young adults. It is an inflammatory demyelination disease...
K. Ravi, K. Arora· Current Neurovascular Resear...· 0 citations
The current body of evidence supports the safety of MSC-based interventions, but their clinical effectiveness has not yet been consistently demonstrated and future progress will depend largely on the standardization of cell preparation and treatment protocols, improved biomarker-driven patient stratification, and rigor...
M. C. Jamali, Alaa Shafie, A. J. Alqahtani et al.· Stem cell research & therape...· 0 citations
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