Gramicidin D as a Multi-Target Antimicrobial Against Staphylococcus aureus: Biofilm Disruption, Virulence Attenuation, Antibiotic Potentiation, and Protein-Peptide Docking Insight.
Jul 2026· Probiotics and Antimicrobial Proteins· 0 citations· 74 references
Medicine
TL;DR
G gramicidin D demonstrated significant antibacterial efficacy against S. aureus and methicillin-resistant S. aureus and exhibited synergistic effects with oxacillin and gentamicin against S. aureus; however, it showed synergy with oxacillin only against MRSA.
NDM-552 is a potent Gram-positive selective antibacterial agent that potentially targets PBP2-associated cell wall biosynthesis and exhibits in vivo efficacy against MRSA.
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