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Open access

Resolving early cochlear inflammation prevents lasting damage from noise exposure

Lauren Barbush Klim Fedorchuk Iman Ezzat V. Manickam Dinesh Y. Gawande Ayden Chavez Marisa Zallocchi
Jul 2026 · bioRxiv · 0 citations · 29 references
Biology Medicine

TL;DR

The utility of a cross-species discovery platform for identifying therapies that preserve sensory function by targeting early inflammatory pathways by identifying quinoxaline derivatives with otoprotective activity following acoustic trauma is demonstrated.

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