Jul 2026· International Journal of Molecular Sciences· Vol 27, pp. 6042· 1 citation· 47 references
Medicine
TL;DR
The expression and roles of SIRTs, especially the most studied family member SIRT 1, are reviewed across several types of human sarcomas, including both bone and soft tissues sarcomas.
Abstract
The mammalian sirtuins (SIRTs), consisting of seven members (SIRT 1–7), are NAD+-dependent histone deacetylases (HDACs). Similar to other classical NAD+-independent HDACs, SIRTs regulate a wide range of key biological processes by deacetylating both histone and non-histone proteins. By linking cellular metabolism to tissue homeostasis, SIRTs play important roles in physiological regulation and are often deregulated in many human diseases including diabetes, neurodegeneration and cancer, particularly sarcomas. Here, we reviewed the expression and roles of SIRTs, especially the most studied family member SIRT 1, across several types of human sarcomas, including both bone and soft tissues sarcomas. We also discussed the clinical relevance of SIRTs and the potential of their modulation as a therapeutic strategy in sarcomas.
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Sirtuins (SIRTs) are a family of proteins involved in diverse cellular processes and play important roles in ageing and the development of osteoarthritis (OA). Among them, SIRT1, SIRT3, and SIRT6 have been identified as key regulators of cartilage homeostasis, primarily through their control of oxidative stress and mod...
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This review focuses on the role of SIRTs 1 & 2 as tumor promoters, providing a rationale for developing inhibitors like sirtinol for these enzymes, and examines sirtinol’s anti-tumor properties in relation to its ability to function as a tridentate iron chelator.
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