The SIRT Family: Subcellular Localization and Main Functions

Abstract

The mammalian sirtuins (SIRTs), consisting of seven members (SIRT 1–7), are NAD+-dependent histone deacetylases (HDACs). Similar to other classical NAD+-independent HDACs, SIRTs regulate a wide range of key biological processes by deacetylating both histone and non-histone proteins. By linking cellular metabolism to tissue homeostasis, SIRTs play important roles in physiological regulation and are often deregulated in many human diseases including diabetes, neurodegeneration and cancer, particularly sarcomas. Here, we reviewed the expression and roles of SIRTs, especially the most studied family member SIRT 1, across several types of human sarcomas, including both bone and soft tissues sarcomas. We also discussed the clinical relevance of SIRTs and the potential of their modulation as a therapeutic strategy in sarcomas.