The g-allele of MDM2-snp309 exhibited a stronger capacity than the t-allele to drive the full-length p2 promoter of the MDM2 gene in several human cell lines, suggesting that the association between MDM2-snp309 and breast cancer is likely multifactorial rather than due to inconsistent gene expression in different cancer sources.
Background The MDM2–p53 signaling pathway plays a central role in tumor suppression, and genetic variants that disrupt this pathway may influence breast cancer (BC) susceptibility. However, data from South Asian populations, particularly Bangladesh, remain limited. Methods A case–control study was conducted in Banglade...
M. H. Chowdhury, Farzana Islam, A. Khan et al.· PLoS ONE· 0 citations
The CYP1A1 rs1048943 polymorphism was not associated with laryngeal cancer susceptibility in this Sudanese cohort, and larger studies are needed to clarify the genetic basis of laryngeal carcinogenesis.
Marwa Abdalwahab, M. Ellaithi· F1000Research· 0 citations
Exonuclease 1 (
EXO1
) is a key nuclease in the DNA mismatch repair (MMR) pathway and is involved in correcting replication errors while maintaining genomic stability. The K589E (rs1047840) single nucleotide polymorphism (SNP) of
EXO1
has been associated with cancer susceptibility in different populations....
Mahmudul Kabir, M. Rahman, Sm Faysal Bellah et al.· Breast Cancer: Basic and Cli...· 0 citations
BACKGROUND
Mutations in the telomerase reverse transcriptase (TERT) promoter region (TPM), particularly C228T and C250T, are common in IDH-wildtype glioblastoma (GBM). The single nucleotide polymorphism (SNP) rs2853669, also located in the TERT promoter, may influence telomerase activity, though its clinical relevance...
Daisuke Kawauchi, Yohei Miyake, B. Taylor et al.· Neuro-Oncology· 0 citations
Background/Aim: Colorectal cancer is the second most common cancer in women and the third most common in men. It is the third leading cause of cancer death worldwide. Statistics suggest a worrying increase in the incidence of this cancer in the coming years. Many factors, including family history, age, smoking habits a...
Mohammad Javan-Fekr, Mohammad-Hossein Sabzevari, I. Saadat· Scripta Medica· 0 citations
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