A systematic review of physiological Ca2+ handling mediated by plasma membrane channels, transporters, and intracellular organelles in the cerebral vasculature emphasizes Ca2+ signaling as a promising therapeutic target to break the vicious cycle of neurovascular impairment and neurodegeneration in AD.
Brain endothelial cells (BECs) are specialized components of the neurovascular unit that couple circulating signals to cerebral blood flow regulation, blood–brain barrier (BBB) function, and selective molecular transport. This narrative review evaluates the correlation of these endothelial functions with psychiatric di...
Meng-Jie Zhang, Xue-Ying Huang, Lin Yao et al.· Frontiers in Cellular Neuros...· 0 citations
This review argues that BIR-driven neurodegeneration should be interpreted at two distinct but interconnected levels: cell-type-specific disruption of brain homeostasis by BIR, and the direct, mechanistic role of BIR in driving the proteinopathies that define Alzheimer’s and Parkinson’s diseases.
Man Xiang, Si-Yu Cao, Xue-Heng Sun et al.· Translational Neurodegenerat...· 0 citations
This review highlights astrocytes as active regulators of BBB integrity and neurovascular unit homeostasis and hypothesizes a key mechanistic link between BBB dysfunction and neurovascular failure in CSVD related to disrupted astrocyte–BBB crosstalk.
Mei Xie, Shuang Wu, Ling Yang et al.· Frontiers in Neurology· 0 citations
An inflammation-centered model is proposed in which BBB breakdown and peripheral immune dysregulation form a pathogenic loop that accelerates neurodegeneration, and targeting this BBB–peripheral immune axis may provide new opportunities for biomarker development, patient stratification, and combination therapy beyond c...
Zu-Li Yang, Zhi-Qiang Xiao, Bin Huang et al.· Frontiers in Immunology· 0 citations
This review proposes conceptualizing Alzheimer's disease as a neural circuit disorder that emerges from sustained crosstalk among multiple interacting pathways, including brain injury, neuroinflammation, mitochondrial and metabolic dysfunction, neurovascular dysfunction, neurovascular dysfunction, synaptic dysfunction,...
Desh Deepak Singh· Current Neuropharmacology· 0 citations
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