Aug 2026· Medicinal Chemistry Research· 0 citations· 152 references
Medicine
TL;DR
Advances in P2Y₁R signaling, pharmacology, and structure-based design are integrated, emphasizing the evolution of nucleotide antagonists and their translational potential, and insights establish P2Y₁R antagonism as a promising strategy for next-generation cardiovascular therapeutics.
Adenosine is a ubiquitous endogenous modulator that coordinates diverse physiological processes by binding to specific adenosine receptors (ARs). Among the four known AR subtypes, A2ARs and A2BRs are critical determinants of cardiovascular homeostasis. This narrative review comprehensively synthesizes current knowled...
Warisara Parichatikanond, Ratchanee Duangrat, N. Nuamnaichati et al.· ACS Pharmacology & Trans...· 0 citations
Through high-throughput screening, this work identified CGS15943 (CGS) as the lead antifibrotic compound and validated its activity in human cardiac fibroblasts, three-dimensional engineered heart tissues, and animal models of HF.
Hao Zhang, Rabindra V. Shivnaraine, Lu Ren et al.· Science· 0 citations
This review aimed to critically synthesize current evidence on the role of coumarins in hypertension management, integrating mechanistic insights, preclinical findings, pharmacokinetic considerations, and available clinical data.
The contributions of class A, class B, and other GPCR families to cardiovascular physiology and pathology are discussed, emphasizing their relevance to the development of targeted interventions for hypertension, heart failure, arrhythmias, atherosclerosis, and related CVDs.
Shaherin Basith, Gwang Lee· Medicinal research reviews (...· 0 citations
A comprehensive overview of multi-level therapeutic strategies directed against the NLRP3 inflammasome is provided, critically evaluates preclinical and clinical evidence—including findings from the CANTOS trial—and discusses the translational potential of NLRP3-targeted immunometabolic therapy in CVDs.
Tian-Qing Zhang, Li Luo, Kai-Lin Yang et al.· Frontiers in Immunology· 1 citation
A narrative review summarizes the evolution of GLP–1–based therapies, highlights emerging dual and triple agonists, and discusses their mechanisms, clinical implications, and safety profiles.
Sandeep Kumar Yadav, Nanda Kumar Yadav, Kalpana Yadav et al.· Journal of Integrative and T...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
