Salidroside alleviates sepsis-associated acute lung injury through modulation of the ERK/FoxO3a signaling axis and improvement of impaired autophagic flux
Salidroside exerts protective effects in sepsis-associated ALI, which may be associated with modulation of the ERK/FoxO3a signaling axis, improvement of impaired autophagic flux, and maintenance of mitochondrial function.
MA attenuates sepsis-associated ALI through anti-inflammatory, antioxidant and anti-apoptotic effects and this mechanism is related to inhibiting the activation of the PI3K/AKT/mTOR signaling pathway.
Zhen Han, Qian Zhang, Bo Cai et al.· Pakistan Journal of Pharmace...· 0 citations
DAP attenuates inflammation and kidney injury in SA-AKI, accompanied by inhibition of non-canonical NF-κB signaling and enhanced autophagic activity and these findings suggest that DAP may represent a promising therapeutic candidate for SAAKI.
Zi-Gang Zhao, Chen Zhang, Xiao-Qiong Zhang et al.· Current Medicinal Chemistry· 0 citations
Findings indicate that ferroptosis and oxidative stress are pivotal in SIDD, and AC was demonstrated to potentially alleviate SIDD by regulating the PI3K/AKT/NRF2 pathway.
It is demonstrated for the first time that Farrerol alleviates HIRI by downregulating macrophage CD14 expression, thereby inhibiting the downstream MyD88/NF-κB pathway and its associated inflammatory cascade, positioning FA as a promising therapeutic candidate and highlighting CD14 as a viable target for HIRI intervent...
Hong-Liang Liang, Jian-Sen Lu, Hao Pan et al.· International Immunopharmaco...· 0 citations
Isoquercitrin mitigates sepsis-induced myocardial injury by targeting the EGFR/PI3K/AKT pathway, thereby inhibiting inflammation and apoptosis and represents a promising therapeutic candidate for sepsis-related cardiac damage.
He-Xin Zhai, Xing-Wei Yang, Yan Shao et al.· Biochemical and Biophysical...· 0 citations
It is suggested that MYR alleviates septic endothelial barrier disruption and MODS, at least in part, by suppressing PAR1-associated NF-κB/NLRP3-mediated endothelial pyroptosis.
Linjun Zhao, Long Zheng, Jiahui Hu et al.· International Immunopharmaco...· 0 citations
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