MicroRNA-223-3p/NLRP3 axis attenuates LPS-induced sepsis-like myocardial dysfunction by suppressing cardiomyocyte pyroptosis

Bi-Xue Zhang Xin Li Qianqian Xu Tingting Wang Yuan-Liang Sun Nurbiya Aji Xin-Tao Zhou Kai-Kai Zhao Yu-Hong Wu Zheng Cheng

Aug 2026 · Molecular Biology Reports · Vol 53 · 0 citations · 34 references

Medicine

TL;DR

It is demonstrated that miR-223-3p attenuates LPS-Induced SLMD by inhibiting the NLRP3 inflammasome and cardiomyocyte pyroptosis and upon treatment with NLRP3 siRNA or a GSDMD-targeting pyroptosis inhibitor disulfiram, miR-223-3p failed to exert additional protective effects against SLMD.

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