Formulation, Optimization, and Evaluation of Gastro-Retentive Floating Beads of Nelfinavir Mesylate Prepared by Emulsion Gelation Technique

Novel Compounding Approach to Floating Alginate Microbeads for Glipizide: Influence of Polymer Matrix on Swelling, Buoyancy, and Drug Release Kinetics.

Effect of Sodium Alginate and Montmorillonite on the Formulation and In Vitro Drug Release of Diclofenac Sodium-Loaded Microbeads

The current research explores how the polymers sodium alginate (SoAl) and montmorillonite (MMT) act as carriers to control the release of diclofenac sodium (DS) from microbeads for an extended period. Microbeads were prepared by the Ionotropic gelation (IG) technique and characterized by Fourier transform in...

Natural Polymer-Based Gastroretentive Floating-Bioadhesive Matrix Tablets of Furosemide: Formulation, Optimization, and in Vitro Evaluation

Background: Furosemide exhibits low and variable oral bioavailability owing to its limited absorption window in the upper gastrointestinal tract, short gastric residence time, and poor aqueous solubility. The present study aimed to develop and optimize a floating-bioadhesive matrix tablet of furosemide using Delonixreg...

Gastro-Retentive Floating Mucoadhesive Zinc Pectinate–Carboxymethyl Cassia Tora Gum IPN Microbeads for Repaglinide: Formulation, Box–Behnken Optimization, and in Vivo Anti-Diabetic Evaluation

Design of experiments for the optimization of mefenamic acid microencapsulation in ec/hpmc cellulose derivatives and drug release improvement using β-cyclodextrin inclusion complex

Mefenamic acid (MA) is one of the low water soluble non-steroidal anti inflammatory drugs (NSAID), exhibiting poor wetting and poor dissolution. MA forms with β-cyclodextrin supramolecular inclusion complexes approving a drug solubility enhancement. The aim of the study is to combine the solubilization capability of a...

Development and Characterization Of Solid Dispersion-Based Immediate-Release Meloxicam Pellets Prepared By Extrusion-Spheronization For Enhanced Solubility and Dissolution

The results show that co-processing solid dispersion with EX-SPONIZATION is an effective and reproducible approach to tackle the solubility constriction of Meloxicam, in which MF3 is the optimized IR formulation.