Orientin: A Promising C-Glycosyl Bioactive Flavonoid with Pharmacological Potential & Therapeutic Perspectives

Abstract

Orientin is a naturally occurring C-glycosyl flavonoid with a variety of pharmacological properties that is found in many medicinal plants. The isolation of orientin Physicochemical Properties, Distribution of tissues, Pharmacological Actions, Pharmacokinetics and In-Silico studies of orientin flavonoid mention in the Review. Exhibit potential Antioxidant, Anticancer, Neuroprotective, Cytoprotective, Antiviral, Anti-inflammatory, Anti-Bacterial, Radioprotective & Antiadipogenic activity has been studied. Such properties are mediated by a number of molecular Pathways, It includes NF-κB, Nrf2/HO-1, PI3K/Akt and apoptotic signalling pathways. Computational research and Molecular docking plays major role and leading point to its potential as a promising phytochemical for further therapeutic development. Also Preclinical results leads to more mechanistic research, Pharmacokinetic optimization, Toxicity assessment and clinical research studies are needed to confirm its therapeutic potential and safety in Humans.